<a id="bm-comp-8cc68be2-424f-49c3-b709-37e07c752171" name="bm-comp-8cc68be2-424f-49c3-b709-37e07c752171" class="BMCustomAnchor"></a><table><tr><td bm-component-id="8cc68be2-424f-49c3-b709-37e07c752171" style="vertical-align: top; width:100.000000%;"><ul><li><font color="#000000">Solid cost control</font></li><li><font color="#1B2634"><font color="#000000">Slower-than-expected patient recruitment</font></font></li><li><font color="#000000">Negative share price reaction expected</font></li></ul></td></tr></table><a id="bm-comp-71cf0a4d-81bb-4f9b-b77d-61c5fa3b876d" name="bm-comp-71cf0a4d-81bb-4f9b-b77d-61c5fa3b876d" class="BMCustomAnchor"></a><table><tr><td bm-component-id="71cf0a4d-81bb-4f9b-b77d-61c5fa3b876d" style="vertical-align: top; width:100.000000%;"><h3 class="bm-h3" style="text-align:left;"><font color="#1B2634"><font color="#000000">Solid cost control</font></font></h3><p style="text-align:left;"><font color="#000000">Net income came in fairly in line with expectations at SEK -15m (vs. ABGSCe at SEX -14m and SEK -13m in Q4'25), with CF from operating activities at SEK -16m (vs. ABGSCe at SEK -14m and SEK -13m in Q4'25). Before the addition of the recent SEK 19m in gross proceeds from exercise of the TO1 warrants, cash and cash equivalents came in at SEK 111m (SEK 127m in Q4'25). With the TO1 proceeds and exercise of the TO2 warrants due in November 2026, we continue to estimate a financial runway into 2028e.</font></p><h3 class="bm-h3" style="text-align:left;"><font color="#1B2634"><font color="#000000">Slower-than-expected patient recruitment</font></font></h3><p style="text-align:left;"><font color="#000000">Isofol today reported slower-than-expected recruitment in its ongoing Phase 1b/2 trial of arfolitixorin in RAS-mutated metastatic colorectal cancer, resulting in the study remaining in the ongoi<font color="#000000">ng 300 mg dose cohort for longer than anticipated.</font> However, the protocol optimisation approved by Germany’s federal regulatory authority BfArM</font> <font color="#000000">in April, including broader inclusion criteria, a direct comparison with leucovorin, and the addition of one further study centre (increasing the number of active sites from one to two), should accelerate enrolment going forward. The recruitment update follo<font color="#000000">ws encouraging interim data presented in February from the first two dose cohorts, where all six evaluable patients experienced tumour shrinkage of up to ~50%,</font> half of the patients improved to such a degree that they were removed from the trial for consideration of surgical removal (rare in this hard-to-treat population), and no dose-limiting toxicities were observed.</font></p><h3 class="bm-h3" style="text-align:left;"><font color="#1B2634"><font color="#000000">Negative</font> share price reaction expected</font></h3><p style="text-align:left;"><font color="#212529"><font color="#000000">The opex in line with expectations, combined with slower-than-expected recruitment, leads us to expect a negative share price reaction today.</font></font></p></td></tr></table>